Collaboration
Currently running collaborative projectsin CCP
- Preclinical safety study for Ctnnb1 foundation (Slovenia)
- Proof of concept study for Bow foundation (USA)
- Proof of concept study for Genteo (CZ)
- Proof of concept study, & preclinical testing for Asgent (CZ)
IMTM: First RD in the program
- Diamond-Blackfan anemia and other ribosomopathies
- Cystic fibrosis
- Hereditary and rare cancers
Preclinical and clinical diagnostic sand therapeutics development at the IMTM
- To provide access to high-end research infrastructure, including genome sequencing, protemics, metabolomics, biobanking, bioinformatics, high-throughput screening technologies, animal imaging and animal models core facilities.
- To provide clinical and preclinical regulatory expertise in development of diagnostics and therapeutics.
- To perform specialized certified services required for the regulatory process (under ISO 17025, ISO 15189, good laboratory practice), etc.
Currently running collaborative projects at IMTM/EATRIS-CZ
- CFTR (Cystic fibrosis transmembrane conductance regulator) modulators – development of cellular models of relevant disease mutations with unmet need, screening candidates for CFTR correctors/modulators.
- Clinical development of fenretinide for cystic fibrosis patients (LaurentPharma)