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2024

Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, Chowdhury A, Dahal D, Methi A, Kaufmann S, Silbern I, Prochazka J, Nichtova Z, Palkova M, Raishbrook M, Koubkova G, Sedlacek R, Tröder SE, Zevnik B, Riedel D, Michanski S, Möbius W, Ströbel P, Lüchtenborg C, Giavalisco P, Urlaub H, Fischer A, Brügger B, Jakobs S, Rehling P Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nat Commun 2024 15(1): 6914. [pubmed] [doi]
Alvarez AM, Trufen CEM, Buri MV, de Sousa MBN, Arruda-Alves FI, Lichtenstein F, Castro de Oliveira U, Junqueira-de-Azevedo ILM, Teixeira C, Moreira V Tumor Necrosis Factor-Alpha Modulates Expression of Genes Involved in Cytokines and Chemokine Pathways in Proliferative Myoblast Cells. Cells 2024 13(13). [pubmed] [doi]
Buccheri V, Pasulka J, Malik R, Loubalova Z, Taborska E, Horvat F, Roos Kulmann MI, Jenickova I, Prochazka J, Sedlacek R, Svoboda P Functional canonical RNAi in mice expressing a truncated Dicer isoform and long dsRNA. EMBO Rep 2024 . [pubmed] [doi]
Candelas Serra M, Kuchtiak V, Kubik-Zahorodna A, Kysilov B, Fili K, Hrcka Krausova B, Abramova V, Dobrovolski M, Harant K, Bozikova P, Cerny J, Prochazka J, Kasparek P, Sedlacek R, Balik A, Smejkalova T, Vyklicky L Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant. J Neurosci 2024 44(31). [pubmed] [doi]
Dlugosova S, Spoutil F, Madureira Trufen CE, Melike Ogan B, Prochazkova M, Fedosieieva O, Nickl P, Aranaz Novaliches G, Sedlacek R, Prochazka J Skeletal dysmorphology and mineralization defects in Fgf20 KO mice. Front Endocrinol (Lausanne) 2024 15: 1286365. [pubmed] [doi]
Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA, , Murray SA, Heaney JD, Nutter LMJ Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines. Sci Rep 2024 14(1): 22626. [pubmed] [doi]
Hampl M, Jandová N, Lusková D, Nováková M, Szotkowská T, Čada Š, Procházka J, Kohoutek J, Buchtová M Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis. Dis Model Mech 2024 17(6). [pubmed] [doi]
Janusova S, Paprckova D, Michalik J, Uleri V, Drobek A, Salyova E, Chorfi L, Neuwirth A, Andreyeva A, Prochazka J, Sedlacek R, Draber P, Stepanek O ABIN1 is a negative regulator of effector functions in cytotoxic T cells. EMBO Rep 2024 . [pubmed] [doi]
Järvelä V, Hamze M, Komulainen-Ebrahim J, Rahikkala E, Piispala J, Kallio M, Kangas SM, Nickl T, Huttula M, Hinttala R, Uusimaa J, Medina I, Immonen EV A novel pathogenic missense variant in epilepsy of infancy with migrating focal seizures causes impaired KCC2 chloride extrusion. Front Mol Neurosci 2024 17: 1372662. [pubmed] [doi]
Kasikova L, Rakova J, Hensler M, Lanickova T, Tomankova J, Pasulka J, Drozenova J, Mojzisova K, Fialova A, Vosahlikova S, Laco J, Ryska A, Dundr P, Kocian R, Brtnicky T, Skapa P, Capkova L, Kovar M, Prochazka J, Praznovec I, Koblizek V, Taskova A, Tanaka H, Lischke R, Mendez FC, Vachtenheim J, Heinzelmann-Schwarz V, Jacob F, McNeish IA, Halaska MJ, Rob L, Cibula D, Orsulic S, Galluzzi L, Spisek R, Fucikova J Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer. Nat Commun 2024 15(1): 2528. [pubmed] [doi]
Nedomova M, Haberecht-Müller S, Möller S, Venz S, Prochazkova M, Prochazka J, Sedlak F, Chawengsaksophak K, Hammer E, Kasparek P, Adamek M, Sedlacek R, Konvalinka J, Krüger E, Grantz Saskova K DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience 2024 27(10): 110893. [pubmed] [doi]
Nickl P, Jenickova I, Elias J, Kasparek P, Barinka C, Kopkanova J, Sedlacek R Multistep allelic conversion in mouse pre-implantation embryos by AAV vectors. Sci Rep 2024 14(1): 20160. [pubmed] [doi]
Novotna E, Milosevic M, Prukova D, Magalhaes-Novais S, Dvorakova S, Dmytruk K, Gemperle J, Zudova D, Nickl T, Vrbacky M, Rosel D, Filimonenko V, Prochazka J, Brabek J, Neuzil J, Rohlenova K, Rohlena J Mitochondrial HER2 stimulates respiration and promotes tumorigenicity. Eur J Clin Invest 2024 , e14174. [pubmed] [doi]
Pavliuchenko N, Kuzmina M, Danek P, Spoutil F, Prochazka J, Skopcova T, Pokorna J, Sedlacek R, Jorda MA, Brdicka T Genetic background affects neutrophil activity and determines the severity of autoinflammatory osteomyelitis in mice. J Leukoc Biol 2024 . [pubmed] [doi]
Pavliuchenko N, Kuzmina M, Danek P, Spoutil F, Prochazka J, Skopcova T, Pokorna J, Sedlacek R, Jorda MA, Brdicka T Genetic background affects neutrophil activity and determines the severity of autoinflammatory osteomyelitis in mice. J Leukoc Biol 2024 . [pubmed] [doi]
Sinigaglia K, Cherian A, Du Q, Lacovich V, Vukić D, Melicherová J, Linhartova P, Zerad L, Stejskal S, Malik R, Prochazka J, Bondurand N, Sedláček R, O'Connell MA, Keegan LP An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation. Cell Rep 2024 43(8): 114618. [pubmed] [doi]
Spoutil F, Dlugosova S, Varga I, Aranaz-Novaliches G, Novosadova V, Prochazkova M, Sedlacek R, Prochazka J Semi-Automated MicroCT Analysis of Bone Anatomy and Mineralization in Mouse Models. Curr Protoc 2024 4(2): e980. [pubmed] [doi]
Sunny SS, Lachova J, Kasparek P, Palkova M, Spoutil F, Prochazka J, Sedlacek R, Liskova P, Kozmik Z Ovol2 promoter mutations in mice and human illuminate species-specific phenotypic divergence. Hum Mol Genet 2024 33(6): 491-500. [pubmed] [doi]
Teboul L, Amos-Landgraf J, Benavides FJ, Birling MC, Brown SDM, Bryda E, Bunton-Stasyshyn R, Chin HJ, Crispo M, Delerue F, Dobbie M, Franklin CL, Fuchtbauer EM, Gao X, Golzio C, Haffner R, Hérault Y, Hrabe de Angelis M, Lloyd KCK, Magnuson TR, Montoliu L, Murray SA, Nam KH, Nutter LMJ, Pailhoux E, Pardo Manuel de Villena F, Peterson K, Reinholdt L, Sedlacek R, Seong JK, Shiroishi T, Smith C, Takeo T, Tinsley L, Vilotte JL, Warming S, Wells S, Whitelaw CB, Yoshiki A, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technolog., Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Asian Mouse Mutagenesis Resource Associ., CELPHEDIA infrast., Pavlovic G Improving laboratory animal genetic reporting: LAG-R guidelines. Nat Commun 2024 15(1): 5574. [pubmed] [doi]
Turkova T, Kokavec J, Zikmund T, Dibus N, Pimkova K, Nemec D, Holeckova M, Ruskova L, Sedlacek R, Cermak L, Stopka T Differential requirements for Smarca5 expression during hematopoietic stem cell commitment. Commun Biol 2024 7(1): 244. [pubmed] [doi]
Ujevic A, Knizkova D, Synackova A, Pribikova M, Trivic T, Dalinskaya A, Drobek A, Niederlova V, Paprckova D, De Guia R, Kasparek P, Prochazka J, Labaj J, Fedosieieva O, Roeck BF, Mihola O, Trachtulec Z, Sedlacek R, Stepanek O, Draber P TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases. Nat Commun 2024 15(1): 10013. [pubmed] [doi]
Vale M, Prochazka J, Sedlacek R Towards a Cure for Diamond-Blackfan Anemia: Views on Gene Therapy. Cells 2024 13(11). [pubmed] [doi]
Varga I, Bakstein E, Gilmore G, May J, Novak D Statistical segmentation model for accurate electrode positioning in Parkinson's deep brain stimulation based on clinical low-resolution image data and electrophysiology. PLoS One 2024 19(3): e0298320. [pubmed] [doi]
Vetyskova V, Hubalek M, Sulc J, Prochazka J, Vondrasek J, Vydra Bousova K Proteolytic profiles of two isoforms of human AMBN expressed in by MMP-20 and KLK-4 proteases. Heliyon 2024 10(2): e24564. [pubmed] [doi]
Vokacova K, Landecka A, Selvi S, Horak J, Novosadova V, Manakova K, Levy M, Vymetalkova V Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of colon cancer patients. Mutagenesis 2024 . [pubmed] [doi]
Zancolli G, von Reumont BM, Anderluh G, Caliskan F, Chiusano ML, Fröhlich J, Hapeshi E, Hempel BF, Ikonomopoulou MP, Jungo F, Marchot P, de Farias TM, Modica MV, Moran Y, Nalbantsoy A, Procházka J, Tarallo A, Tonello F, Vitorino R, Zammit ML, Antunes A Web of venom: exploration of big data resources in animal toxin research. Gigascience 2024 13. [pubmed] [doi]

2023

Benes J, Kroupova K, Kotrc M, Petrak J, Jarolim P, Novosadova V, Kautzner J, Melenovsky V FGF-23 is a biomarker of RV dysfunction and congestion in patients with HFrEF. Sci Rep 2023 13(1): 16004. [pubmed] [doi]
Benova A, Ferencakova M, Bardova K, Funda J, Prochazka J, Spoutil F, Cajka T, Dzubanova M, Balcaen T, Kerckhofs G, Willekens W, van Lenthe GH, Charyyeva A, Alquicer G, Pecinova A, Mracek T, Horakova O, Coupeau R, Hansen MS, Rossmeisl M, Kopecky J, Tencerova M Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity. Commun Biol 2023 6(1): 1043. [pubmed] [doi]
Bianchini F, Crivelli V, Abernathy ME, Guerra C, Palus M, Muri J, Marcotte H, Piralla A, Pedotti M, De Gasparo R, Simonelli L, Matkovic M, Toscano C, Biggiogero M, Calvaruso V, Svoboda P, Cervantes Rincón T, Fava T, Podešvová L, Shanbhag AA, Celoria A, Sgrignani J, Stefanik M, Hönig V, Pranclova V, Michalcikova T, Prochazka J, Guerrini G, Mehn D, Ciabattini A, Abolhassani H, Jarrossay D, Uguccioni M, Medaglini D, Pan-Hammarström Q, Calzolai L, Fernandez D, Baldanti F, Franzetti-Pellanda A, Garzoni C, Sedlacek R, Ruzek D, Varani L, Cavalli A, Barnes CO, Robbiani DF Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein. Sci Immunol 2023 , eade0958. [pubmed] [doi]
Cutano V, Ferreira Mendes JM, Escudeiro-Lopes S, Machado S, Vinaixa Forner J, Gonzales-Morena JM, Prevorovsky M, Zemlianski V, Feng Y, Kralova Viziova P, Hartmanova A, Malcekova B, Jakoube P, Iyer S, Keckesova Z LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. Life Sci Alliance 2023 6(1). [pubmed] [doi]
Demkova L, Bugajev V, Utekal P, Kuchar L, Schuster B, Draber P, Halova I Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep 2023 13(1): 9615. [pubmed] [doi]
Gruper Y, Wolff ASB, Glanz L, Spoutil F, Marthinussen MC, Osickova A, Herzig Y, Goldfarb Y, Aranaz-Novaliches G, Dobeš J, Kadouri N, Ben-Nun O, Binyamin A, Lavi B, Givony T, Khalaila R, Gome T, Wald T, Mrazkova B, Sochen C, Besnard M, Ben-Dor S, Feldmesser E, Orlova EM, Hegedűs C, Lampé I, Papp T, Felszeghy S, Sedlacek R, Davidovich E, Tal N, Shouval DS, Shamir R, Guillonneau C, Szondy Z, Lundin KEA, Osicka R, Prochazka J, Husebye ES, Abramson J Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease. Nature 2023 624(7992): 653-662. [pubmed] [doi]
Holicek P, Truxova I, Rakova J, Salek C, Hensler M, Kovar M, Reinis M, Mikyskova R, Pasulka J, Vosahlikova S, Remesova H, Valentova I, Lysak D, Holubova M, Kaspar P, Prochazka J, Kasikova L, Spisek R, Galluzzi L, Fucikova J Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients. Cell Death Dis 2023 14(3): 209. [pubmed] [doi]
Hyrossova P, Milosevic M, Alghadi AY, Kucera L, Prochazka J, Sedlacek R, Rohlena J, Rohlenova K Spatial Analysis of Nucleotide Metabolism: From CRISPR Knockout Cancer Cells to MALDI Imaging of Tumors. Methods Mol Biol 2023 2675: 297-308. [pubmed] [doi]
Chee JM, Lanoue L, Clary D, Higgins K, Bower L, Flenniken A, Guo R, Adams DJ, Bosch F, Braun RE, Brown SDM, Chin HG, Dickinson ME, Hsu CW, Dobbie M, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Mammano F, Nutter LMJ, Parkinson H, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y, Brooks B, McKerlie C, Lloyd KCK, Westerberg H, Moshiri A Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. BMC Biol 2023 21(1): 22. [pubmed] [doi]
Chowdhury A, Boshnakovska A, Aich A, Methi A, Vergel Leon AM, Silbern I, Lüchtenborg C, Cyganek L, Prochazka J, Sedlacek R, Lindovsky J, Wachs D, Nichtova Z, Zudova D, Koubkova G, Fischer A, Urlaub H, Brügger B, Katschinski DM, Dudek J, Rehling P Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome. EMBO Mol Med 2023 15(9): e17399. [pubmed] [doi]
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity. Cell Mol Life Sci 2023 80(5): 135. [pubmed] [doi]
Karnošová A, Strnadová V, Zelezna B, Kunes J, Kašpárek P, Maletinska L NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose. Clin Sci (Lond) 2023 137(10): 847-62. [pubmed] [doi]
Krausová M, Kreplová M, Banik P, Cvačková Z, Kubovčiak J, Modrák M, Zudová D, Lindovský J, Kubik-Zahorodna A, Pálková M, Kolář M, Procházka J, Sedláček R, Staněk D Retinitis pigmentosa-associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells. Life Sci Alliance 2023 6(6). [pubmed] [doi]
Kubik-Zahorodna A, Prochazka J, Sedlacek R Behavioral Characterization of an Angelman Syndrome Mouse Model. J Vis Exp 2023 (200). [pubmed] [doi]
Lindovsky J, Nichtova Z, Dragano NRV, Pajuelo Reguera D, Prochazka J, Fuchs H, Marschall S, Gailus-Durner V, Sedlacek R, Hrabě de Angelis M, Rozman J, Spielmann N A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice. Mamm Genome 2023 34(2): 107-122. [pubmed] [doi]
Lindovsky J, Palkova M, Symkina V, Raishbrook MJ, Prochazka J, Sedlacek R OCT and ERG Techniques in High-Throughput Phenotyping of Mouse Vision. Genes (Basel) 2023 14(2). [pubmed] [doi]
Mejdrová I, Dušek J, Škach K, Stefela A, Skoda J, Chalupský K, Dohnalová K, Pavkova I, Kronenberger T, Rashidian A, Smutná L, Duchoslav V, Smutny T, Pávek P, Nencka R Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-]pyridine Structure. J Med Chem 2023 66(4): 2422-2456. [pubmed] [doi]
Menezes PR, Trufen CEM, Lichtenstein F, Pellegrina DVDS, Reis EM, Onuki J Transcriptome profile analysis reveals putative molecular mechanisms of 5-aminolevulinic acid toxicity. Arch Biochem Biophys 2023 738: 109540. [pubmed] [doi]
Mizerovská D, Špoutil F., Claude J., Lavrenchenko L. A., Procházka J., Bryja J., Mikula O. Parallel Evolution of Skull Form in Three Rodent Genera Inhabiting Steep Elevational Gradients of Ethiopian Highlands Evolutionary Biology 2023 50(Jul 23): 332-349. [doi]
Musiol S, Harris CP, Karlina R, Gostner JM, Rathkolb B, Schnautz B, Schneider E, Mair L, Vergara EE, Flexeder C, Koletzko S, Bauer CP, Schikowski T, Berdel D, von Berg A, Herberth G, Rozman J, Hrabe de Angelis M, Standl M, Schmidt-Weber CB, Ussar S, Alessandrini F Dietary digestible carbohydrates are associated with higher prevalence of asthma in humans and with aggravated lung allergic inflammation in mice. Allergy 2023 78(5): 1218-1233. [pubmed] [doi]
Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, Clary D, Dew EM, Elfertak L, Guimond A, Haseli Mashhadi H, Heaney JD, Kelsey L, Keskivali-Bond P, Lopez Gomez F, Marschall S, McFarland M, Meziane H, Munoz Fuentes V, Nam KH, Nichtová Z, Pimm D, Bower L, Prochazka J, Rozman J, Santos L, Stewart M, Tanaka N, Ward CS, Willett AME, Wilson R, Braun RE, Dickinson ME, Flenniken AM, Herault Y, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Sedlacek R, Seong JK, Sorg T, Tamura M, Wells S, Schneltzer E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, White JK, Spielmann N Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mamm Genome 2023 34(2): 180-199. [pubmed] [doi]
Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nat Commun 2023 14(1): 3092. [pubmed] [doi]
Pinto BF, Lopes PH, Trufen CEM, Ching ATC, De Azevedo ILMJ, Nishiyama MY, Pohl PC, Tambourgi DV Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by Loxosceles sphingomyelinases D. Arch Toxicol 2023 97(12): 3285-3301. [pubmed] [doi]
Sojka L, Opattova A, Bartu L, Horak J, Korenkova V, Novosadova V, Krizkova V, Bruha J, Liska V, Schneiderova M, Kubecek O, Vodickova L, Urbanova M, Simsa J, Vodicka P, Vymetalkova V MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes. Oncol Lett 2023 25(2): 72. [pubmed] [doi]
Spoutil F, Aranaz-Novaliches G, Prochazkova M, Wald T, Novosadova V, Kasparek P, Osicka R, Reseland JE, Lyngstadaas SP, Tiainen H, Bousova K, Vondrasek J, Sedlacek R, Prochazka J Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions. Sci Rep 2023 13(1): 1471. [pubmed] [doi]
Stopková R, Matějková T, Dodoková A, Talacko P, Zacek P, Sedlacek R, Piálek J, Stopka P Variation in mouse chemical signals is genetically controlled and environmentally modulated. Sci Rep 2023 13(1): 8573. [pubmed] [doi]
Syding LA, Kubik-Zahorodna A, Reguera DP, Nickl P, Hruskova B, Kralikova M, Kopkanova J, Novosadova V, Kasparek P, Prochazka J, Rozman J, Turecek R, Sedlacek R Ablation of Gabra5 Influences Corticosterone Levels and Anxiety-like Behavior in Mice. Genes (Basel) 2023 14(2). [pubmed] [doi]
Takayasu BS, Rodrigues SS, Madureira Trufen CE, Machado-Santelli GM, Onuki J Effects on cell cycle progression and cytoskeleton organization of five spp. venoms in cell culture-based assays. Heliyon 2023 9(7): e18317. [pubmed] [doi]

2022

Aranaz-Novaliches G, Spoutil F, Bukova I, Krejzova I, Olsinova M, Dalecka M, Benda A, Rozman J, Sedlacek R, Prochazka J Multi-Level Approach for Comprehensive Enamel Phenotyping. Curr Protoc 2022 2(1): e340. [pubmed] [doi]
Benova A, Ferencakova M, Bardova K, Funda J, Prochazka J, Spoutil F, Cajka T, Dzubanova M, Balcaen T, Kerckhofs G, Willekens W, van Lenthe GH, Alquicer G, Pecinova A, Mracek T, Horakova O, Rossmeisl M, Kopecky J, Tencerova M Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones. Mol Metab 2022 65: 101598. [pubmed] [doi]
De Guia RM, Zatecka V, Rozman J, Prochazka J, Sedlacek R Full Assessment of Lung Mechanics Using Computer-Controlled, Forced Oscillation Technique. Curr Protoc 2022 2(7): e488. [pubmed] [doi]
Dibus N, Zobalova E, Monleon MAM, Korinek V, Filipp D, Petrusova J, Sedlacek R, Kasparek P, Cermak L FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Front Cell Dev Biol 2022 10: 914053. [pubmed] [doi]
Engelhard CA, Huang C, Khani S, Kasparek P, Prochazka J, Rozman J, Reguera DP, Sedlacek R, Kornfeld JW Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA . Noncoding RNA 2022 8(3). [pubmed] [doi]
Gazdarica M, Noda J, Durydivka O, Novosadova V, Mackie K, Pin JP, Prezeau L, Blahos J SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein-coupled receptor kinase 3 signalosome. J Neurochem 2022 . [pubmed] [doi]
Gonzalez-Morena JM, Escudeiro-Lopes S, Ferreira-Mendes JM, Jakoube P, Cutano V, Vinaixa-Forner J, Kralova Viziova P, Hartmanova A, Sedlacek R, Machado S, Malcekova B, Keckesova Z LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Apoptosis 2022 . [pubmed] [doi]
Günes Günsel G, Conlon TM, Jeridi A, Kim R, Ertüz Z, Lang NJ, Ansari M, Novikova M, Jiang D, Strunz M, Gaianova M, Hollauer C, Gabriel C, Angelidis I, Doll S, Pestoni JC, Edelmann SL, Kohlhepp MS, Guillot A, Bassler K, Van Eeckhoutte HP, Kayalar Ö, Konyalilar N, Kanashova T, Rodius S, Ballester-López C, Genes Robles CM, Smirnova N, Rehberg M, Agarwal C, Krikki I, Piavaux B, Verleden SE, Vanaudenaerde B, Königshoff M, Dittmar G, Bracke KR, Schultze JL, Watz H, Eickelberg O, Stoeger T, Burgstaller G, Tacke F, Heissmeyer V, Rinkevich Y, Bayram H, Schiller HB, Conrad M, Schneider R, Yildirim AÖ The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun 2022 13(1): 1303. [pubmed] [doi]
Higgins K, Moore BA, Berberovic Z, Adissu HA, Eskandarian M, Flenniken AM, Shao A, Imai DM, Clary D, Lanoue L, Newbigging S, Nutter LMJ, Adams DJ, Bosch F, Braun RE, Brown SDM, Dickinson ME, Dobbie M, Flicek P, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Chin HG, Mammano F, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y, , Lloyd KCK, McKerlie C, Moshiri A Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes. Sci Rep 2022 12(1): 20791. [pubmed] [doi]
Holubova J, Stanek O, Juhasz A, Hamidou Soumana I, Makovicky P, Sebo P The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model. PLoS Pathog 2022 18(4): e1010402. [pubmed] [doi]
Hrdý J, Couturier-Maillard A, Boutillier D, Lapadatescu C, Blanc P, Procházka J, Pot B, Ryffel B, Grangette C, Chamaillard M Oral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis. Sci Rep 2022 12(1): 17591. [pubmed] [doi]
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Iatsiuk V, Malinka F, Pickova M, Tureckova J, Klema J, Spoutil F, Novosadova V, Prochazka J, Sedlacek R Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns. BMC Gastroenterol 2022 22(1): 186. [pubmed] [doi]
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Klimova N, Holubova J, Streparola G, Tomala J, Brazdilova L, Stanek O, Bumba L, Sebo P Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes. PLoS Pathog 2022 18(6): e1010577. [pubmed] [doi]
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Kostka L, Sivák L, Šubr V, Kovářová J, Šírová M, Říhová B, Sedlacek R, Etrych T, Kovář M Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance. Biomacromolecules 2022 . [pubmed] [doi]
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Kučera L, Moos M, Štětina T, Korbelová J, Vodrážka P, Des Marteaux L, Grgac R, Hůla P, Rozsypal J, Faltus M, Šimek P, Sedlacek R, Koštál V A mixture of innate cryoprotectants is key for freeze tolerance and cryopreservation of a drosophilid fly larva. J Exp Biol 2022 225(8). [pubmed] [doi]
Kunze P, Kreiss L, Novosadová V, Roehe AV, Steinmann S, Prochazka J, Geppert CI, Hartmann A, Schürmann S, Friedrich O, Schneider-Stock R Multiphoton Microscopy Reveals DAPK1-Dependent Extracellular Matrix Remodeling in a Chorioallantoic Membrane (CAM) Model. Cancers (Basel) 2022 14(10). [pubmed] [doi]
Magalhaes-Novais S, Blecha J, Naraine R, Mikesova J, Abaffy P, Pecinova A, Milosevic M, Bohuslavova R, Prochazka J, Khan S, Novotna E, Sindelka R, Machan R, Dewerchin M, Vlcak E, Kalucka J, Stemberkova Hubackova S, Benda A, Goveia J, Mracek T, Barinka C, Carmeliet P, Neuzil J, Rohlenova K, Rohlena J Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Autophagy 2022 , 1-18. [pubmed] [doi]
Malinka F, Zareie A, Prochazka J, Sedlacek R, Novosadova V Batch alignment via retention orders for preprocessing large-scale multi-batch LC-MS experiments. Bioinformatics 2022 . [pubmed] [doi]
Minařík L, Pimková K, Kokavec J, Schaffartziková A, Vellieux F, Kulvait V, Daumová L, Dusilková N, Jonášová A, Vargová KS, Králová Viziová P, Sedláček R, Zemanová Z, Stopka T Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways. Cells 2022 11(2). [pubmed] [doi]
Paprckova D, Niederlova V, Moudra A, Drobek A, Pribikova M, Janusova S, Schober K, Neuwirth A, Michalik J, Huranova M, Horkova V, Cesnekova M, Simova M, Prochazka J, Balounova J, Busch DH, Sedlacek R, Schwarzer M, Stepanek O Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections. Front Immunol 2022 13: 1009198. [pubmed] [doi]
Pavliuchenko N, Duric I, Kralova J, Fabisik M, Spoutil F, Prochazka J, Kasparek P, Pokorna J, Skopcova T, Sedlacek R, Brdicka T Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Front Immunol 2022 13: 1035226. [pubmed] [doi]
Png G, Gerlini R, Hatzikotoulas K, Barysenka A, Rayner NW, Klarić L, Rathkolb B, Aguilar-Pimentel JA, Rozman J, Fuchs H, Gailus-Durner V, Tsafantakis E, Karaleftheri M, Dedoussis G, Pietrzik C, Wilson JF, Angelis MH, Becker-Pauly C, Gilly A, Zeggini E Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing. Hum Mol Genet 2022 . [pubmed] [doi]
Prochazkova M, Budinska E, Kuzma M, Pelantova H, Hradecky J, Heczkova M, Daskova N, Bratova M, Modos I, Videnska P, Splichalova P, Sowah SA, Kralova M, Henikova M, Selinger E, Klima K, Chalupsky K, Sedlacek R, Landberg R, Kühn T, Gojda J, Cahova M Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross-Sectional Multi-Omics Study. Front Nutr 2022 8: 783302. [pubmed] [doi]
Skoda J, Dohnalova K, Chalupsky K, Stahl A, Templin M, Maixnerova J, Micuda S, Grøntved L, Braeuning A, Pavek P Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice. Biochem Pharmacol 2022 197: 114905. [pubmed] [doi]
Súkeníková L, Černý V, Věcek J, Petrásková P, Novotná O, Vobruba Š, Michalčíková T, Procházka J, Kolářová L, Prokešová L, Hrdý J The Impact of Escherichia coli Probiotic Strain O83:K24:H31 on the Maturation of Dendritic Cells and Immunoregulatory Functions In Vitro and In Vivo. Cells 2022 11(10). [pubmed] [doi]
Syding LA, Kubik-Zahorodna A, Nickl P, Novosadova V, Kopkanova J, Kasparek P, Prochazka J, Sedlacek R Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Gene. Cells 2022 11(18). [pubmed] [doi]
Vacurova E, Trnovska J, Svoboda P, Skop V, Novosadova V, Reguera DP, Petrezselyová S, Piavaux B, Endaya B, Spoutil F, Zudova D, Stursa J, Melcova M, Bielcikova Z, Werner L, Prochazka J, Sedlacek R, Huttl M, Hubackova SS, Haluzik M, Neuzil J Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. Nat Commun 2022 13(1): 1866. [pubmed] [doi]
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Wellbrock AHJ, Eckhardt LRH, Kelsey NA, Heldmaier G, Rozman J, Witte K Cool birds: first evidence of energy-saving nocturnal torpor in free-living common swifts resting in their nests. Biol Lett 2022 18(4): 20210675. [pubmed] [doi]
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Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol Cell 2022 82(21): 4064-4079.e13. [pubmed] [doi]

2021

Bechynska K, Kosek V, Fenclova M, Muchova L, Smid V, Suk J, Chalupsky K, Sticova E, Hurkova K, Hajslova J, Vitek L, Stranska M The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. Biomolecules 2021 11(11). [pubmed] [doi]
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Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, , Teboul L, Murray SA A resource of targeted mutant mouse lines for 5,061 genes. Nat Genet 2021 53(4): 416-419. [pubmed] [doi]
Birling MC, Fray MD, Kasparek P, Kopkanova J, Massimi M, Matteoni R, Montoliu L, Nutter LMJ, Raspa M, Rozman J, Ryder EJ, Scavizzi F, Voikar V, Wells S, Pavlovic G, Teboul L Importing genetically altered animals: ensuring quality. Mamm Genome 2021 . [pubmed] [doi]
Bugajev V, Paulenda T, Utekal P, Mrkacek M, Halova I, Kuchar L, Kuda O, Vavrova P, Schuster B, Fuentes-Liso S, Potuckova L, Smrz D, Cernohouzova S, Draberova L, Bambouskova M, Draber P Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. J Lipid Res 2021 , 100121. [pubmed] [doi]
Bukova I, Szczerkowska KI, Prochazkova M, Beck IM, Prochazka J, Sedlacek R Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate. Front Cell Dev Biol 2021 9: 620692. [pubmed] [doi]
Cervena K, Novosadova V, Pardini B, Naccarati A, Opattova A, Horak J, Vodenkova S, Buchler T, Skrobanek P, Levy M, Vodicka P, Vymetalkova V Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients. Front Oncol 2021 11: 702258. [pubmed] [doi]
Čaja F, Stakheev D, Chernyavskiy O, Křížan J, Dvořák J, Rossmann P, Štěpánková R, Makovický P, Makovický P, Kozáková H, Vannucci L Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions. J Immunotoxicol 2021 18(1): 37-49. [pubmed] [doi]
Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell 2021 . [pubmed] [doi]
De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarström Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. Nature 2021 . [pubmed] [doi]
de Guia RM, Hassing AS, Ma T, Plucinska K, Holst B, Gerhart-Hines Z, Emanuelli B, Treebak JT Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake. FASEB J 2021 35(5): e21450. [pubmed] [doi]
Düsterhöft S, Kahveci-Türköz S, Wozniak J, Seifert A, Kasparek P, Ohm H, Liu S, Kopkanova J, Lokau J, Garbers C, Preisinger C, Sedlacek R, Freeman M, Ludwig A The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release. Cell Mol Life Sci 2021 . [pubmed] [doi]
Dvorakova M, Kubik-Zahorodna A, Straiker A, Sedlacek R, Hajkova A, Mackie K, Blahos J SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB receptors. Br J Pharmacol 2021 178(7): 1588-1604. [pubmed] [doi]
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Ezrova Z, Nahacka Z, Stursa J, Werner L, Vlcak E, Kralova Viziova P, Berridge MV, Sedlacek R, Zobalova R, Rohlena J, Boukalova S, Neuzil J SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy. Oncogene 2021 40(14): 2539-2552. [pubmed] [doi]
Fabisik M, Tureckova J, Pavliuchenko N, Kralova J, Balounova J, Vicikova K, Skopcova T, Spoutil F, Pokorna J, Angelisova P, Malissen B, Prochazka J, Sedlacek R, Brdicka T Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1. Front Immunol 2021 12: 618332. [pubmed] [doi]
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Gresakova V, Novosadova V, Prochazkova M, Prochazka J, Sedlacek R Dual role of Fam208a during zygotic cleavage and early embryonic development. Exp Cell Res 2021 406(2): 112723. [pubmed] [doi]
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Hejdánková Z., Vanek V., Sedlák F., Procházka J., Diederichs A., Kereiche S., Novotná B., Budesinsky M., Birkus G., Grantz Saskova K., Cígler P. Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery ADVANCED FUNCTIONAL MATERIALS 2021 31(47): 2101391. [doi]
Holubova J, Juhasz A, Masin J, Stanek O, Jurnecka D, Osickova A, Sebo P, Osicka R Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Botdetella pertussis Int J Mol Sci 2021 22(21). [pubmed] [doi]
Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development 2021 148(10). [pubmed] [doi]
Karmon G, Sragovich S, Hacohen-Kleiman G, Ben-Horin-Hazak I, Kasparek P, Schuster B, Sedlacek R, Pasmanik-Chor M, Theotokis P, Touloumi O, Zoidou S, Huang L, Wu PY, Shi R, Kapitansky O, Lobyntseva A, Giladi E, Shapira G, Shomron N, Bereswill S, Heimesaat MM, Grigoriadis N, McKinney RA, Rubinstein M, Gozes I Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies. Biol Psychiatry 2021 S0006-3223(21): 01630-9. [pubmed] [doi]
Kim R, Yu T, Li J, Prochazka J, Sharir A, Green JBA, Klein OD Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development. Development 2021 148(14). [pubmed] [doi]
Kralova J, Pavliuchenko N, Fabisik M, Ilievova K, Spoutil F, Prochazka J, Pokorna J, Sedlacek R, Brdicka T The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis. J Biol Chem 2021 297(4): 101131. [pubmed] [doi]
Krausova A, Buresova P, Sarnova L, Oyman-Eyrilmez G, Skarda J, Wohl P, Bajer L, Sticova E, Bartonova L, Pacha J, Koubkova G, Prochazka J, Spörrer M, Dürrbeck C, Stehlikova Z, Vit M, Ziolkowska N, Sedlacek R, Jirak D, Kverka M, Wiche G, Fabry B, Korinek V, Gregor M Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunol 2021 14(3): 691-702. [pubmed] [doi]
Lassi M, Tomar A, Comas-Armangué G, Vogtmann R, Dijkstra DJ, Corujo D, Gerlini R, Darr J, Scheid F, Rozman J, Aguilar-Pimentel A, Koren O, Buschbeck M, Fuchs H, Marschall S, Gailus-Durner V, Hrabe de Angelis M, Plösch T, Gellhaus A, Teperino R Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors. Sci Adv 2021 7(22). [pubmed] [doi]
Lidak T, Baloghova N, Korinek V, Sedlacek R, Balounova J, Kasparek P, Cermak L CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. Int J Mol Sci 2021 22(10). [pubmed] [doi]
Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M, Damme M LAMP3 deficiency affects surfactant homeostasis in mice. PLoS Genet 2021 17(6): e1009619. [pubmed] [doi]
Malandra A, Rahman WU, Klimova N, Streparola G, Holubova J, Osickova A, Bariselli S, Sebo P, Osicka R Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein. Int J Mol Sci 2021 22(16). [pubmed] [doi]
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Splichalova I, Balounová J, Vobořil M, Brabec T, Sedlacek R, Filipp D Deletion of TLR2 erythro-myeloid progenitors leads to embryonic lethality in mice. Eur J Immunol 2021 . [pubmed] [doi]
Šedová L, Prochazka J, Zudová D, Bendlová B, Včelák J, Sedlacek R, Šeda O Heterozygous Mutation Affects Glucose Tolerance in Male Rats. Genes (Basel) 2021 12(7). [pubmed] [doi]
Šedová L, Buková I, Bažantová P, Petrezsélyová S, Prochazka J, Školníková E, Zudová D, Včelák J, Makovický P, Bendlová B, Šeda O, Sedlacek R Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Gene. Int J Mol Sci 2021 22(8). [pubmed] [doi]
Takáč T, Křenek P, Komis G, Vadovič P, Ovečka M, Ohnoutková L, Pechan T, Kašpárek P, Tichá T, Basheer J, Arick M, Šamaj J TALEN-Based Knock-Out Attenuates Proteome and Root Hair Phenotypic Responses to flg22 in Barley. Front Plant Sci 2021 12: 666229. [pubmed] [doi]
Tsyklauri O, Niederlova V, Forsythe E, Prasai A, Drobek A, Kasparek P, Sparks K, Trachtulec Z, Prochazka J, Sedlacek R, Beales P, Huranova M, Stepanek O Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO Rep 2021 , e50785. [pubmed] [doi]
Vendramin R, Katopodi V, Cinque S, Konnova A, Knezevic Z, Adnane S, Verheyden Y, Karras P, Demesmaeker E, Bosisio FM, Kucera L, Rozman J, Gladwyn-Ng I, Rizzotto L, Dassi E, Millevoi S, Bechter O, Marine JC, Leucci E Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma. J Exp Med 2021 218(9). [pubmed] [doi]
Vidali S, Gerlini R, Thompson K, Urquhart JE, Meisterknecht J, Aguilar-Pimentel JA, Amarie OV, Becker L, Breen C, Calzada-Wack J, Chhabra NF, Cho YL, da Silva-Buttkus P, Feichtinger RG, Gampe K, Garrett L, Hoefig KP, Hölter SM, Jameson E, Klein-Rodewald T, Leuchtenberger S, Marschall S, Mayer-Kuckuk P, Miller G, Oestereicher MA, Pfannes K, Rathkolb B, Rozman J, Sanders C, Spielmann N, Stoeger C, Szibor M, Treise I, Walter JH, Wurst W, Mayr JA, Fuchs H, Gärtner U, Wittig I, Taylor RW, Newman WG, Prokisch H, Gailus-Durner V, Hrabě de Angelis M Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes. EMBO Mol Med 2021 13(12): e14397. [pubmed] [doi]
Woo XY, Giordano J, Srivastava A, Zhao ZM, Lloyd MW, de Bruijn R, Suh YS, Patidar R, Chen L, Scherer S, Bailey MH, Yang CH, Cortes-Sanchez E, Xi Y, Wang J, Wickramasinghe J, Kossenkov AV, Rebecca VW, Sun H, Mashl RJ, Davies SR, Jeon R, Frech C, Randjelovic J, Rosains J, Galimi F, Bertotti A, Lafferty A, O'Farrell AC, Modave E, Lambrechts D, Ter Brugge P, Serra V, Marangoni E, El Botty R, Kim H, Kim JI, Yang HK, Lee C, Dean DA, Davis-Dusenbery B, Evrard YA, Doroshow JH, Welm AL, Welm BE, Lewis MT, Fang B, Roth JA, Meric-Bernstam F, Herlyn M, Davies MA, Ding L, Li S, Govindan R, Isella C, Moscow JA, Trusolino L, Byrne AT, Jonkers J, Bult CJ, Sedláček R., Medico E, Chuang JH, , Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 2021 53(1): 86-99. [pubmed] [doi]
Xing L, Kubik-Zahorodna A, Namba T, Pinson A, Florio M, Prochazka J, Sarov M, Sedlacek R, Huttner WB Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. EMBO J 2021 , e107093. [pubmed] [doi]
Zbodakova O, Chalupsky K, Sarnova L, Kasparek P, Jirouskova M, Gregor M, Sedlacek R ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Sci Rep 2021 11(1): 11414. [pubmed] [doi]

2020

Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. Clin Sci (Lond) 2020 134(7): 727-746. [pubmed] [doi]
Bayram J, Malcova I, Sinkovec L, Holubova J, Streparola G, Jurnecka D, Kucera J, Sedlacek R, Sebo P, Kamanova J Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue. PLoS Pathog 2020 16(8): e1008512. [pubmed] [doi]
Budinska E, Gojda J, Heczkova M, Bratova M, Dankova H, Wohl P, Bastova H, Lanska V, Kostovcik M, Dastych M, Senkyrik M, Krizova J, Mraz M, Hradecky J, Hajslova J, Lenicek M, Podzimkova K, Chalupsky K, Sedlacek R, Cahova M Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment. JPEN J Parenter Enteral Nutr 2020 44(1): 105-118. [pubmed] [doi]
Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D, , Human and mouse essentiality screens as a resource for disease gene discovery. Nat Commun 2020 11(1): 655. [pubmed] [doi]
de Guia RM Stress, glucocorticoid signaling pathway, and metabolic disorders. Diabetes Metab Syndr 2020 14(5): 1273-1280. [pubmed] [doi]
Desideri F, Cipriano A, Petrezselyova S, Buonaiuto G, Santini T, Kasparek P, Prochazka J, Janson G, Paiardini A, Calicchio A, Colantoni A, Sedlacek R, Bozzoni I, Ballarino M Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1. Cell Rep 2020 33(12): 108548. [pubmed] [doi]
Huttl M, Markova I, Miklankova D, Oliyarnyk O, Trnovska J, Kucera J, Sedlacek R, Haluzik M, Malinska H Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model. J Physiol Pharmacol 2020 71(5). [pubmed] [doi]
Jenickova I, Kasparek P, Petrezselyova S, Elias J, Prochazka J, Kopkanova J, Navratil M, Barinka C, Sedlacek R Efficient allele conversion in mouse zygotes and primary cells based on electroporation of Cre protein. Methods 2020 S1046-2023(20): 30114-6. [pubmed] [doi]
Jerabkova K, Liao Y, Kleiss C, Fournane S, Durik M, Agote-Arán A, Brino L, Sedlacek R, Sumara I Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis. FASEB J 2020 34(9): 12751-12767. [pubmed] [doi]
Keipert S, Lutter D, Schroeder BO, Brandt D, Ståhlman M, Schwarzmayr T, Graf E, Fuchs H, de Angelis MH, Tschöp MH, Rozman J, Jastroch M Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. Nat Commun 2020 11(1): 624. [pubmed] [doi]
Kračun D, Klop M, Knirsch A, Petry A, Kanchev I, Chalupsky K, Wolf CM, Görlach A NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess. Redox Biol 2020 34: 101536. [pubmed] [doi]
Kralova J, Drobek A, Prochazka J, Spoutil F, Fabisik M, Glatzova D, Borna S, Pokorna J, Skopcova T, Angelisova P, Gregor M, Kovarik P, Sedlacek R, Brdicka T Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis. J Immunol 2020 204(6): 1607-1620. [pubmed] [doi]
Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM The Deep Genome Project. Genome Biol 2020 21(1): 18. [pubmed] [doi]
Makovický P, Makovický P Histological aspects of skeletal muscle fibers splitting of C57BL/6NCrl mice. Physiol Res 2020 69(2): 291-296. [pubmed] [doi]
Malinka F, Železný F, Kléma J Finding semantic patterns in omics data using concept rule learning with an ontology-based refinement operator. BioData Min 2020 13: 13. [pubmed] [doi]
Sabol M, Akbudak MA, Fricova D, Beck I, Sedlacek R Novel TALEN-generated mCitrine-FANCD2 fusion reporter mouse model for in vivo research of DNA damage response. DNA Repair (Amst) 2020 94: 102936. [pubmed] [doi]
Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nat Commun 2020 11(1): 296. [pubmed] [doi]
Seifert A, Wozniak J, Düsterhöft S, Kasparek P, Sedlacek R, Dreschers S, Orlikowsky TW, Yildiz D, Ludwig A The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. Int J Mol Sci 2020 21(17). [pubmed] [doi]
Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, Martinez S, Wu M, Häring HU, de Angelis MH, Beckers J, Müller TD, Stemmer K, Wurst W, Rozman J, Nogueiras R, De Angelis M, Molkentin JD, Krahmer N, Yi CX, Schmidt MV, Luquet S, Heni M, Tschöp MH, Pfluger PT Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. J Clin Invest 2020 130(11): 6093-6108. [pubmed] [doi]
Skoda J, Dusek J, Drastik M, Stefela A, Dohnalova K, Chalupsky K, Smutny T, Micuda S, Gerbal-Chaloin S, Pavek P Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain. Cells 2020 9(12). [pubmed] [doi]
Swan AL, Schütt C, Rozman J, Del Mar Muñiz Moreno M, Brandmaier S, Simon M, Leuchtenberger S, Griffiths M, Brommage R, Keskivali-Bond P, Grallert H, Werner T, Teperino R, Becker L, Miller G, Moshiri A, Seavitt JR, Cissell DD, Meehan TF, Acar EF, Lelliott CJ, Flenniken AM, Champy MF, Sorg T, Ayadi A, Braun RE, Cater H, Dickinson ME, Flicek P, Gallegos J, Ghirardello EJ, Heaney JD, Jacquot S, Lally C, Logan JG, Teboul L, Mason J, Spielmann N, McKerlie C, Murray SA, Nutter LMJ, Odfalk KF, Parkinson H, Prochazka J, Reynolds CL, Selloum M, Spoutil F, Svenson KL, Vales TS, Wells SE, White JK, Sedlacek R, Wurst W, Lloyd KKC, Croucher PI, Fuchs H, Williams GR, Bassett D, Gailus-Durner V, Herault Y, Mallon AM, Brown SDM, Mayer-Kuckuk P, Hrabe de Angelis M, Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS Genet 2020 16(12): e1009190. [pubmed] [doi]
Syding LA, Nickl P, Kasparek P, Sedlacek R CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review. Cells 2020 9(4). [pubmed] [doi]
Vobořil M, Brabec T, Dobeš J, Šplíchalová I, Březina J, Čepková A, Dobešová M, Aidarova A, Kubovčiak J, Tsyklauri O, Štěpánek O, Beneš V, Sedláček R, Klein L, Kolář M, Filipp D Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. Nat Commun 2020 11(1): 2361. [pubmed] [doi]
Zhang T, Xie P, Dong Y, Liu Z, Zhou F, Pan D, Huang Z, Zhai Q, Gu Y, Wu Q, Tanaka N, Obata Y, Bradley A, Lelliott CJ, , Nutter LMJ, McKerlie C, Flenniken AM, Champy MF, Sorg T, Herault Y, Angelis MH, Durner VG, Mallon AM, Brown SDM, Meehan T, Parkinson HE, Smedley D, Lloyd KCK, Yan J, Gao X, Seong JK, Wang CL, Sedlacek R, Liu Y, Rozman J, Yang L, Xu Y High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genet 2020 16(1): e1008577. [pubmed] [doi]
Ziak J, Weissova R, Jeřábková K, Janikova M, Maimon R, Petrasek T, Pukajova B, Kleisnerova M, Wang M, Brill MS, Kasparek P, Zhou X, Alvarez-Bolado G, Sedlacek R, Misgeld T, Stuchlik A, Perlson E, Balastik M CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. EMBO Rep 2020 , e48512. [pubmed] [doi]

2019

Badiu Tișa I, Samașca G, Aldea C, Lupan I, Farcau D, Makovicky P Ganglioneuroblastoma in children. Neurol Sci 2019 40(9): 1985-1989. [pubmed] [doi]
Baláži A, Sirotkin AV, Földešiová M, Makovický P, Chrastinová Ľ, Makovický P, Chrenek P Green tea can supress rabbit ovarian functions in vitro and in vivo. Theriogenology 2019 127: 72-79. [pubmed] [doi]
Balounová J, Šplíchalová I, Dobešová M, Kolář M, Fišer K, Procházka J, Sedlacek R, Jurisicova A, Sung HK, Kořínek V, Alberich-Jorda M, Godin I, Filipp D Toll-like receptor 2 expression on c-kit cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nat Commun 2019 10(1): 5176. [pubmed] [doi]
Bechynska K, Daskova N, Vrzackova N, Harant K, Heczková M, Podzimkova K, Bratova M, Dankova H, Berkova Z, Kosek V, Zelenka J, Hajslova J, Sedlacek R, Suttnar J, Hlavackova A, Bartonova L, Cahova M The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration. Sci Rep 2019 9(1): 19097. [pubmed] [doi]
Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis 2019 10(11): 818. [pubmed] [doi]
Gresakova V, Novosadova V, Prochazkova M, Bhargava S, Jenickova I, Prochazka J, Sedlacek R Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Exp Cell Res 2019 382(1): 111437. [pubmed] [doi]
Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol 2019 20(1): 171. [pubmed] [doi]
Huebner K, Procházka J, Monteiro AC, Mahadevan V, Schneider-Stock R The activating transcription factor 2: an influencer of cancer progression. Mutagenesis 2019 34(5-6): 375-389. [pubmed] [doi]
Janeckova L, Kostovcikova K, Svec J, Stastna M, Strnad H, Kolar M, Hudcovic T, Stancikova J, Tureckova J, Baloghova N, Sloncova E, Galuskova K, Tlaskalova-Hogenova H, Korinek V Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice. Int J Mol Sci 2019 20(7). [pubmed] [doi]
Kaiser K, Gyllborg D, Procházka J, Salašová A, Kompaníková P, Molina FL, Laguna-Goya R, Radaszkiewicz T, Harnoš J, Procházková M, Potěšil D, Barker RA, Casado ÁG, Zdráhal Z, Sedláček R, Arenas E, Villaescusa JC, Bryja V WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nat Commun 2019 10(1): 1498. [pubmed] [doi]
Kaspar P, Prochazka J, Efenberkova M, Juhasz A, Novosadova V, Sedlacek R c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells. Sci Rep 2019 9(1): 6342. [pubmed] [doi]
Kovalčíková J, Vrbacký M, Pecina P, Tauchmannová K, Nůsková H, Kaplanová V, Brázdová A, Alán L, Eliáš J, Čunátová K, Kořínek V, Sedlacek R, Mráček T, Houštěk J TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme. FASEB J 2019 33(12): 14103-14117. [pubmed] [doi]
Lustyk D, Kinský S, Ullrich KK, Yancoskie M, Kašíková L, Gergelits V, Sedlacek R, Chan YF, Odenthal-Hesse L, Forejt J, Jansa P Genomic Structure of Modifier of -Dependent Hybrid Male Sterility in Mice. Genetics 2019 213(3): 1047-1063. [pubmed] [doi]
Markova I, Miklankova D, Hüttl M, Kacer P, Skibova J, Kucera J, Sedlacek R, Kacerova T, Kazdova L, Malinska H The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach. J Diabetes Res 2019 2019: 8712979. [pubmed] [doi]
Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL, Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z Histone methyltransferase PRDM9 is not essential for meiosis in male mice. Genome Res 2019 29(7): 1078-1086. [pubmed] [doi]
Nováková M, Hampl M, Vrábel D, Procházka J, Petrezselyová S, Procházková M, Sedláček R, Kavková M, Zikmund T, Kaiser J, Juan HC, Fann MJ, Buchtová M, Kohoutek J Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13. Front Cell Dev Biol 2019 7: 155. [pubmed] [doi]
Pokrývková B, Saláková M, Šmahelová J, Vojtěchová Z, Novosadová V, Tachezy R Detailed Characteristics of Tonsillar Tumors with Extrachromosomal or Integrated Form of Human Papillomavirus. Viruses 2019 12(1). [pubmed] [doi]
Szczerkowska KI, Petrezselyova S, Lindovsky J, Palkova M, Dvorak J, Makovicky P, Fang M, Jiang C, Chen L, Shi M, Liu X, Zhang J, Kubik-Zahorodna A, Schuster B, Beck IM, Novosadova V, Prochazka J, Sedlacek R Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the mimic human disease phenotype. Cell Biosci 2019 9: 21. [pubmed] [doi]
Taborska E, Pasulka J, Malik R, Horvat F, Jenickova I, Jelić Matošević Z, Svoboda P Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes. PLoS Genet 2019 15(12): e1008261. [pubmed] [doi]
Vorlová B, Sedlák F, Kašpárek P, Šrámková K, Malý M, Zámečník J, Šácha P, Konvalinka J A novel PSMA/GCPII-deficient mouse model shows enlarged seminal vesicles upon aging. Prostate 2019 79(2): 126-139. [pubmed] [doi]
Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D Aire-expressing ILC3-like cells in the lymph node display potent APC features. J Exp Med 2019 216(5): 1027-1037. [pubmed] [doi]
Zikmund T, Kokavec J, Turkova T, Savvulidi F, Paszekova H, Vodenkova S, Sedlacek R, Skoultchi AI, Stopka T ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection. J Immunol 2019 202(12): 3434-3446. [pubmed] [doi]

2018

Forte A, Grossi M, Bancone C, Cipollaro M, De Feo M, Hellstrand P, Persson L, Nilsson BO, Della Corte A Polyamine concentration is increased in thoracic ascending aorta of patients with bicuspid aortic valve. Heart Vessels 2018 33(3): 327-339. [pubmed] [doi]
Horn M, Zbodakova O, Kasparek P, Srp J, Haneckova R, Hradilek M, Mares M, Sedlacek R Profiling system for skin kallikrein proteolysis applied in gene-deficient mouse models. Biol Chem 2018 399(9): 1085-1089. [pubmed] [doi]
Horvat F, Fulka H, Jankele R, Malik R, Jun M, Solcova K, Sedlacek R, Vlahovicek K, Schultz RM, Svoboda P Role of Cnot6I in maternal mRNA turnover Life Sci Alliance 2018 1(4): e201800084. [pubmed] [doi]
Indrová M, Rossowska J, Pajtasz-Piasecka E, Mikyšková R, Richter J, Rosina J, Sedláček R, Fišerová A The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain Oncology Letters 2018 15(3): 3594-3601. [pubmed] [doi]
Jirouskova M, Nepomucka K, Oyman-Eyrilmez G, Kalendova A, Havelkova H, Sarnova L, Chalupsky K, Schuster B, Benada O, Miksatkova P, Kuchar M, Fabian O, Sedlacek R, Wiche G, Gregor M Plectin controls biliary tree architecture and stability in cholestasis. J Hepatol 2018 68(5): 1006-1017. [pubmed] [doi]
Klein P, Sojka M, Kucera J, Matonohova J, Pavlik V, Nemec J, Kubickova G, Slavkovsky R, Szuszkiewicz K, Danek P, Rozkot M, Velebny V A porcine model of skin wound infected with a polybacterial biofilm. Biofouling 2018 34(2): 226-236. [pubmed] [doi]
Kral J, Korenkova V, Novosadova V, Langerova L, Schneiderova M, Liska V, Levy M, Veskrnova V, Spicak J, Opattova A, Jiraskova K, Vymetalkova V, Vodicka P, Slyskova J Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis 2018 39(11): 1359-1367. [pubmed] [doi]
Krupková M, Liška F, Kazdová L, Šedová L, Kábelová A, Křenová D, Křen V, Šeda O Single-Gene Congenic Strain Reveals the Effect of on Dexamethasone-Induced Insulin Resistance. Front Endocrinol (Lausanne) 2018 9: 185. [pubmed] [doi]
Magnen M, Elsässer BM, Zbodakova O, Kasparek P, Gueugnon F, Petit-Courty A, Sedlacek R, Goettig P, Courty Y Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases. Biol Chem 2018 399(9): 1053-1064. [pubmed] [doi]
Makovický P, Chrenková M, Makovický P, Fľak P, Formelová Z, Novosadová V, Rajský M, Vannucci L The effect of selected feed mixtures on the duodenal morphology: comparison study. Physiol Res 2018 67(6): 955-962. [pubmed]
Mucksová J, Chalupský K, Plachý J, Kalina J, Rachacová P, Stanek O, Trefil P Simultaneous detection of chicken cytokines in plasma samples using the Bio-Plex assay. Poult Sci 2018 97(4): 1127-1133. [pubmed] [doi]
Newton AH, Spoutil F, Prochazka J, Black JR, Medlock K, Paddle RN, Knitlova M, Hipsley CA, Pask AJ Letting the 'cat' out of the bag: pouch young development of the extinct Tasmanian tiger revealed by X-ray computed tomography. R Soc Open Sci 2018 5(2): 171914. [pubmed] [doi]
Prochazkova M, Prochazka J, Marangoni P, Klein OD Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development. Front Genet 2018 9: 542. [pubmed] [doi]
Ramirez J, Lectez B, Osinalde N, Sivá M, Elu N, Aloria K, Procházková M, Perez C, Martínez-Hernández J, Barrio R, Šašková KG, Arizmendi JM, Mayor U Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Hum Mol Genet 2018 27(11): 1955-1971. [pubmed] [doi]
Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H, , Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun 2018 9(1): 288. [pubmed] [doi]
Sapega O, Mikyšková R, Bieblová J, Mrázková B, Hodný Z, Reiniš M Distinct phenotypes and 'bystander' effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines. Int J Oncol 2018 53(5): 1997-2009. [pubmed] [doi]
Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Cell Mol Life Sci 2018 . [pubmed] [doi]
Sirotkin AV, Kadasi A, Stochmalova A, Balazi A, Földesiová M, Makovicky P, Chrenek P, Harrath AH Effect of turmeric on the viability, ovarian folliculogenesis, fecundity, ovarian hormones and response to luteinizing hormone of rabbits. Animal 2018 12(6): 1242-1249. [pubmed] [doi]
Šedová L, Školníková E, Hodúlová M, Včelák J, Šeda O, Bendlová B Expression profiling of Nme7 interactome in experimental models of metabolic syndrome. Physiol Res 2018 67(Supplementum 3): S543-S550. [pubmed]
Zarska M, Sramek M, Novotny F, Havel F, Babelova A, Mrazkova B, Benada O, Reinis M, Stepanek I, Musilek K, Bartek J, Ursinyova M, Novak O, Dzijak R, Kuca K, Proska J, Hodny Z Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Biomaterials 2018 154: 275-290. [pubmed] [doi]

2017

Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep 2017 7(1): 9322. [pubmed] [doi]
Dong LF, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam AK, Sedlacek R, Oliveira PJ, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. Elife 2017 6. [pubmed] [doi]
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet 2017 13(1): e1006566. [pubmed] [doi]
Kim S, Prochazka J, Bush JO Live Imaging of Mouse Secondary Palate Fusion. J Vis Exp 2017 (125). [pubmed] [doi]
Kostiv U, Rajsiglová L, Luptáková D, Pluháček T, Vannucci L, Havlíček V, Engstová H, Jirák D, Šlouf M, Makovický P, Sedláček R, Horák D Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models RSC Advances 2017 7(85): 45997-46006. [doi]
Makovický P, Matlach R, Makovický P, Švecová I, Samasca G Injury of the brain and liver capillaries in lethal car accidents Rom J Leg Med 2017 25: 351-358.
Makovicky P, Makovicky P, Lupan I, Samasca G, Sur G, Freeman HJ Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels. Adv Nutr 2017 8(3): 409-411. [pubmed] [doi]
Makovicky P, Tumova E, Volek Z, Makovicky P, Arnone JM, Svecova I, Samasca G The influence of food restriction on the small bowel: Does intensive short‑term food restriction lead to weight loss? Bratisl Lek Listy 2017 118(6): 361-365. [pubmed] [doi]
Mikyskova R, Indrova M, Stepanek I, Kanchev I, Bieblova J, Vosahlikova S, Moserova I, Truxova I, Fucikova J, Bartunkova J, Spisek R, Sedlacek R, Reinis M Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice. Oncoimmunology 2017 6(12): e1362528. [pubmed] [doi]
Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res 2017 32(11): 2219-2231. [pubmed] [doi]
Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development 2017 144(12): 2212-2221. [pubmed] [doi]
Samasca G, Lerner A, Girbovan A, Sur G, Lupan I, Makovicky P, Matthias T, Freeman HJ Challenges in gluten-free diet in coeliac disease: Prague consensus. Eur J Clin Invest 2017 47(5): 394-397. [pubmed] [doi]
Samasca G, Sur G, Lupan I, Makovicky P, Freeman HJ Challenges in the celiac disease diagnosis; Prague consensus. Gastroenterol Hepatol Bed Bench 2017 10(1): 1-2. [pubmed]
Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta 2017 1864(1): 217-230. [pubmed] [doi]
Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis. Infect Immun 2017 85(6). [pubmed] [doi]
Šeda O, Liška F, Pravenec M, Vernerová Z, Kazdová L, Křenová D, Zídek V, Šedová L, Krupková M, Křen V Connexin 50 mutation lowers blood pressure in spontaneously hypertensive rat. Physiol Res 2017 66(1): 15-28. [pubmed]
Šeda O, Šedová L, Včelák J, Vaňková M, Liška F, Bendlová B ZBTB16 and metabolic syndrome: a network perspective. Physiol Res 2017 66(Supplementum 3): S357-S365. [pubmed]
Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A 2017 114(9): E1641-E1650. [pubmed] [doi]
Žbodáková O, Chalupský K, Turečková J, Sedláček R Metalloproteinases in liver fibrosis: current insights Metalloproteinases In Medicine 2017 4: 25 - 35.

2016

Brauer R, Turečková J, Kanchev I, Khoylou M, Škarda J, Procházka J, Spoutil F, Beck IM, Žbodáková O, Kašpárek P, Kořínek V, Chalupský K, Karhu T, Herzig KH, Hajduch M, Gregor M, Sedláček R MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol 2016 9(4): 974-85. [pubmed] [doi]
Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet 2016 12(8): e1006174. [pubmed] [doi]
Du W, Prochazka J, Prochazkova M, Klein OD Expression of FGFs during early mouse tongue development. Gene Expr Patterns 2016 20(2): 81-7. [pubmed] [doi]
Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie 2016 122: 99-109. [pubmed] [doi]
Fišerová A, Richter J, Čapková K, Bieblová J, Mikyšková R, Reiniš M, Indrová M Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors. Int J Oncol 2016 49(2): 763-72. [pubmed] [doi]
Hodny Z, Reinis M, Hubackova S, Vasicova P, Bartek J Interferon gamma/NADPH oxidase defence system in immunity and cancer OncoImmunology 2016 5(2): 1-7. [doi]
Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. Oncogene 2016 35(10): 1236-49. [pubmed] [doi]
Janečková L, Fafílek B, Krausová M, Horázná M, Vojtěchová M, Alberich-Jorda M, Šloncová E, Galušková K, Sedláček R, Anděrová M, Kořínek V Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity. Genesis 2016 54(3): 101-14. [pubmed] [doi]
Jankovicova J, Frolikova M, Sebkova N, Simon M, Cupperova P, Lipcseyova D, Michalkova K, Horovska L, Sedlacek R, Stopka P, Antalikova J, Dvorakova-Hortova K Characterization of tetraspanin protein CD81 in mouse spermatozoa and bovine gametes. Reproduction 2016 152(6): 785-793. [pubmed] [doi]
Kasparek P, Ileninova Z, Haneckova R, Kanchev I, Jenickova I, Sedlacek R A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene. Biol Chem 2016 397(12): 1287-1292. [pubmed] [doi]
Kubik-Zahorodna A, Schuster B, Kanchev I, Sedláček R Neurological Deficits of an Rps19(Arg67del) Model of Diamond-Blackfan Anaemia. Folia Biol (Praha) 2016 62(4): 139-47. [pubmed]
Makovicky P, Tumova E, Volek Z, Makovicky P, Sedlacek R Relationships between variable time, percentage of food restriction and liver histology: which alternative is the best for non-alcoholic fatty liver disease (NAFLD) prevention? Histol Histopathol 2016 31(10): 1123-30. [pubmed] [doi]
Mikyšková R, Štěpánek I, Indrová M, Bieblová J, Šímová J, Truxová I, Moserová I, Fučíková J, Bartůňková J, Špíšek R, Reiniš M Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol 2016 48(3): 953-64. [pubmed] [doi]
Moudra A, Hubackova S, Machalova V, Vancurova M, Bartek J, Reinis M, Hodny Z, Jonasova A Dynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine. Oncoimmunology 2016 5(10): e1183860. [pubmed] [doi]
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis. Oncotarget 2016 7(14): 17431-41. [pubmed] [doi]
Roque A, Petrezsélyová S, Serra-Cardona A, Ariño J Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress. BMC Genomics 2016 17: 662. [pubmed] [doi]
Simova J, Sapega O, Imrichova T, Stepanek I, Kyjacova L, Mikyskova R, Indrova M, Bieblova J, Bubenik J, Bartek J, Hodny Z, Reinis M Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines. Oncotarget 2016 7(34): 54952-54964. [pubmed] [doi]
Šeda O, Křenová D, Oliyarnyk O, Šedová L, Krupková M, Liška F, Chylíková B, Kazdová L, Křen V Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat. Lipids Health Dis 2016 15(1): 199. [pubmed] [doi]
Šedová L, Pravenec M, Křenová D, Kazdová L, Zídek V, Krupková M, Liška F, Křen V, Šeda O Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model. PLoS One 2016 11(3): e0152708. [pubmed] [doi]
Vernerova L, Spoutil F, Vlcek M, Krskova K, Penesova A, Meskova M, Marko A, Raslova K, Vohnout B, Rovensky J, Killinger Z, Jochmanova I, Lazurova I, Steiner G, Smolen J, Imrich R A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study. PLoS One 2016 11(4): e0153316. [pubmed] [doi]
Vrbacký M, Kovalčíková J, Chawengsaksophak K, Beck IM, Mráček T, Nůsková H, Sedmera D, Papoušek F, Kolář F, Sobol M, Hozák P, Sedlacek R, Houštěk J Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet 2016 . [pubmed] [doi]

2015

Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep 2015 13(4): 812-28. [pubmed] [doi]
Beck IM, Sedlacek R TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground. Transgenic Res 2015 24(1): 179-83. [pubmed] [doi]
Chalupsky K, Kračun D, Kanchev I, Bertram K, Görlach A Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Antioxid Redox Signal 2015 23(14): 1076-91. [pubmed] [doi]
Kaspar P, Zikova M, Bartunek P, Sterba J, Strnad H, Kren L, Sedlacek R The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin. Sci Rep 2015 5: 15090. [pubmed] [doi]
Meehan TF, Chen CK, Koscielny G, Relac M, Wilkinson P, Flicek P, Parkinson H, Castro A, Fessele S, Steinkamp R, Hagn M, Raess M, de Angelis MH, Bottomley J, Ramirez-Solis R, Smedley D, Ball S, Blake A, Fray M, Kenyon J, Mallon AM, Brown S, Massimi M, Matteoni R, Tocchini-Valentini G, Herault Y, Kollias G, Fleming A, Ulfhake B, Demengeot J, Fremond C, Bosch F, Montoliu L, Soininen R, Schughart K, Brakebusch C, Sedlacek R, Rülicke T, McKerlie C, Malissen B, Iraqi F, Jonkers J, Russig H, Huylebroeck D INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Res 2015 43(Database issue): D1171-5. [pubmed] [doi]
Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell 2015 35(6): 713-24. [pubmed] [doi]
Stancikova J, Krausova M, Kolar M, Fafilek B, Svec J, Sedlacek R, Neroldova M, Dobes J, Horazna M, Janeckova L, Vojtechova M, Oliverius M, Jirsa M, Korinek V NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling. Cell Signal 2015 27(2): 245-56. [pubmed] [doi]
Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet 2015 24(15): 4340-52. [pubmed] [doi]

2014

Cervinková M, Horák P, Kanchev I, Matěj R, Fanta J, Sequens R, Kašpárek P, Sarnová L, Turečková J, Sedláček R Differential expression and processing of matrix metalloproteinase 19 marks progression of gastrointestinal diseases. Folia Biol (Praha) 2014 60(3): 113-22. [pubmed]
Flemr M, Moravec M, Libova V, Sedlacek R, Svoboda P Lin28a is dormant, functional, and dispensable during mouse oocyte-to-embryo transition. Biol Reprod 2014 90(6): 131. [pubmed] [doi]
Gregor M, Osmanagic-Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G, Resch GP, Jörgl A, Herrmann H, Wiche G Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J 2014 28(2): 715-29. [pubmed] [doi]
Harten SK, Bruxner TJ, Bharti V, Blewitt M, Nguyen TM, Whitelaw E, Epp T The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Mamm Genome 2014 25(7-8): 293-303. [pubmed] [doi]
Chalupnikova K, Solc P, Sulimenko V, Sedlacek R, Svoboda P An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes. Cell Cycle 2014 13(7): 1187-200. [pubmed] [doi]
Kasparek P, Krausova M, Haneckova R, Kriz V, Zbodakova O, Korinek V, Sedlacek R Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS Lett 2014 588(21): 3982-8. [pubmed] [doi]
Liss A, Ooi CH, Zjablovskaja P, Benoukraf T, Radomska HS, Ju C, Wu M, Balaštík M, Delwel R, Brdička T, Tan P, Tenen DG, Alberich-Jorda M The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors. Haematologica 2014 99(4): 697-705. [pubmed] [doi]
Prukova D, Ileninova Z, Antosova B, Kasparek P, Gregor M, Sedlacek R Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes. Physiol Res 2014 . [pubmed]
Sperrhacke M, Fischer J, Wu Z, Klünder S, Sedlacek R, Schroeder JM, Meyer-Hoffert U, Reiss K SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. J Invest Dermatol 2014 134(6): 1645-54. [pubmed] [doi]

2013

Buryova H, Chalupský K, Žbodáková O, Kanchev I, Jiroušková M, Gregor M, Sedláček R Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity. BMC Gastroenterol 2013 13(1): 155. [pubmed] [doi]
Daxinger L, Harten S, Oey H, Epp T, Isbel L, Huang E, Whitelaw N, Apedaile A, Sorolla A, Yong J, Bharti V, Sutton J, Ashe A, Pang ZY, Wallace N, Gerhardt DJ, Blewitt ME, Jeddeioh JA, Whitelaw E An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol 2013 14(9): R96. [pubmed] [doi]
Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. Gastroenterology 2013 144(2): 381-91. [pubmed] [doi]
Flemr M, Malik R, Franke V, Nejepinska J, Sedlacek R, Vlahovicek K, Svoboda P A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell 2013 155(4): 807-16. [pubmed] [doi]
Chalupský K, Kanchev I, Žbodáková O, Buryová H, Jiroušková M, Kořínek V, Gregor M, Sedláček R ADAM10/17-dependent release of soluble c-Met correlates with hepatocellular damage. Folia Biol (Praha) 2013 59(2): 76-86. [pubmed]
Klimova L, Lachova J, Machon O, Sedlacek R, Kozmik Z Generation of mRx-Cre transgenic mouse line for efficient conditional gene deletion in early retinal progenitors. PLoS One 2013 8(5): e63029. [pubmed] [doi]
Youngson NA, Epp T, Roberts AR, Daxinger L, Ashe A, Huang E, Lester KL, Harten SK, Kay GF, Cox T, Matthews JM, Chong S, Whitelaw E No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mamm Genome 2013 24(5-6): 206-17. [pubmed] [doi]

2012

Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest 2012 122(12): 4490-504. [pubmed] [doi]
Gao L, Siu KL, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension 2012 59(1): 158-66. [pubmed] [doi]
Jirouskova M, Zbodakova O, Gregor M, Chalupsky K, Sarnova L, Hajduch M, Ehrmann J, Jirkovska M, Sedlacek R Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis. PLoS One 2012 7(10): e46271. [pubmed] [doi]
Kasparek P, Krenek P, Buryova H, Suchanova S, Beck IM, Sedlacek R Transgenic mouse model expressing tdTomato under involucrin promoter as a tool for analysis of epidermal differentiation and wound healing. Transgenic Res 2012 21(3): 683-9. [pubmed] [doi]
Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K Structural and functional concepts in current mouse phenotyping and archiving facilities. J Am Assoc Lab Anim Sci 2012 51(4): 418-35. [pubmed]
Laššuthová P, Gregor M, Sarnová L, Machalová E, Sedláček R, Seeman P Clinical, In Silico, and Experimental Evidence for Pathogenicity of Two Novel Splice Site Mutations in the SH3TC2 Gene. J Neurogenet 2012 26(3-4): 413-20. [pubmed] [doi]

2011

Brauer R, Beck IM, Roderfeld M, Roeb E, Sedlacek R Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen. BMC Biochem 2011 12: 38. [pubmed] [doi]
Chan KC, Ko JM, Lung HL, Sedlacek R, Zhang ZF, Luo DZ, Feng ZB, Chen S, Chen H, Chan KW, Tsao SW, Chua DT, Zabarovsky ER, Stanbridge EJ, Lung ML Catalytic activity of Matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma. Int J Cancer 2011 129(8): 1826-37. [pubmed] [doi]
Reiss K, Meyer-Hoffert U, Fischer J, Sperrhacke M, Wu Z, Dimitrieva O, Krenek P, Suchanova S, Buryova H, Brauer R, Sedlacek R Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2. Exp Dermatol 2011 20(11): 905-10. [pubmed] [doi]

2010

Lettau I, Hattermann K, Held-Feindt J, Brauer R, Sedlacek R, Mentlein R Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells. J Neuropathol Exp Neurol 2010 69(3): 215-23. [pubmed] [doi]
Lokossou AA, Rietman H, Wang M, Krenek P, van der Schoot H, Henken B, Hoekstra R, Vleeshouwers VG, van der Vossen EA, Visser RG, Jacobsen E, Vosman B Diversity, distribution, and evolution of Solanum bulbocastanum late blight resistance genes. Mol Plant Microbe Interact 2010 23(9): 1206-16. [pubmed] [doi]
Müller M, Beck IM, Gadesmann J, Karschuk N, Paschen A, Proksch E, Djonov V, Reiss K, Sedlacek R MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells. Mod Pathol 2010 23(4): 511-21. [pubmed] [doi]
Sarnova L, Malik R, Sedlacek R, Svoboda P Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes. J Negat Results Biomed 2010 9: 8. [pubmed] [doi]

2008

Beck IM, Rückert R, Brandt K, Mueller MS, Sadowski T, Brauer R, Schirmacher P, Mentlein R, Sedlacek R MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses. PLoS One 2008 3(6): e2343. [pubmed] [doi]